GLP-1 Myths Busted: Desensitization, Damage, and Downregulation Explained If you need assistance in your journey to reach your weight loss goals, book a consultation with me: ✨ Join Dr. Dan’s Empowerment Hub 👉 Discover sustainable, evidence-based solutions to transform your health and embrace self-care without guilt. Connect with a supportive community, get daily affirmations, and create lasting vitality. Don’t wait—click to learn more and start your journey today! Join this channel to get access to perks: Download my FREE GLP-1/GIP Medication Information Sheet and 7-Day Food Journal: Try my fancy dancy Total Daily Energy Expenditure (TDEE) Calculator: Subscribe to the channel: – Have you ever heard someone say that GLP-1 medications like Wegovy, Ozempic, or Zepbound stop working over time—or worse, that they damage your GLP-1 receptors? Some even suggest cycling off these medications to “reset” your system. Let me set the record straight. In this video, I’m busting myths about desensitization, damage, and downregulation of GLP-1 receptors. I’ll walk you through the science of how these medications actually work, why they don’t “wear out” your receptors, and what real-world studies like SELECT and STEP 5 tell us. (Spoiler: these meds keep doing their job even when weight loss slows down.) We’ll talk about the realities of weight-loss plateaus, how your body’s natural metabolic adaptations come into play, and why cycling off these meds might make it harder to reach or maintain your goals. I’ll also share why managing expectations is so important and how to navigate the noise from influencers and misinformation online. Thanks for watching! 00:00 Introduction 00:40 GLP-1 Receptor Agonist Recap 01:34 Studies on desensitization or down-regulation 02:13 Dr. Dan’s Empowerment Hub 03:03 SELECT & STEP 5 Trials 04:45 Plateaus post-weight loss & grand expectations 06:24 So what’s going on? 08:11 Yesoul Fitness Bike - promo: DRDAN 09:11 Cycling medication & the Surmount 4 Trial 10:25 Yo-yo dieting 11:05 Final thoughts – Watch my previous videos about how to fight obesity and about the best medicine for weight loss: ▪️ Food Noise: ▪️ Watch This Before Taking Mounjaro: ▪️ From Ozempic to Mounjaro: ▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: ▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: ▪️ Ozempic: Stomach Paralysis Update: ▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: ▪️ Ozempic Paralyzed My Stomach: ▪️ How to Inject Mounjaro: step-by-step tutorial: Products I recommend to support your weight-loss journey: ▪️ Managing Constipation: ▪️ Managing Diarrhea: ▪️ Managing Heartburn: ▪️ Internalized Weight Bias: ▪️ Protein Bars: ▪️ Scales and More: ▪️ Supplements: ▪️ Activity Trackers I recommend: ▪️ My favorite Books: 🇺🇸 USA: 🇨🇦 Canada: – Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy - – Sign up for my newsletter: – Contact Me: [email protected] – For more about weight loss via habit mastery, visit Join me on social media: ▪️ ▪️ Disclaimer of Medical Liability. HEALTHCARE EVOLUTION INC. DOES NOT PROVIDE MEDICAL ADVICE. The content of this material is for general informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Reliance on any information provided here is solely at your own risk. Individual medical needs are very different; you should not assume that the information in this document concerning certain courses of treatment or outcomes will apply to you. 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Aired: May 11, 2025
