@doctorstotrust presents episode 2205 | DR BEN BIKMAN Dr Ben Bikman's dissertation work done in first GLP-1 lab in gastric-bypass procedures--as guts were re-plumbed, led to profound differences in GLP-1 -many gut hormones were changed with this surgery -GLP-1 is a natural hormone made by intestines Endocrine organs: thyroid, adrenals, gonads Brain , heart, muscle, bone makes hormones GLP-1 agonist: drug that, when injected, dials up GLP-1 signal to a superphysiological level… -early on in this drug testing, the dose was low, and it: -only inhibited glucagon [opposite effect of insulin] -quick and substantial drop in blood glucose -resolving T2D quite well -and, as little side effect, people ate a little less Now: at 5X dose: used as weight loss drug: Paralysis of the Intestines--main action -food stays in stomach 24+ hours GLP-1 is a metabolic advantage...we want it -protein intake will increase it; fat intake will increase it -some carbs do; so does fiber [stimulate L cells that make it] Can take advantage of GLP-1's satiety effect due to slowing down digestion Problem with these drugs: Slows Down Digestion Too Much -in some cases: permanent paralysis of intestines -must get nutrition thru infusion Rest of Life -and have colostomy bag |||||||||||||||||||||||||||||||| doctorstotrust.com healthresults.com insuliniq.com hlthcode.com original video interview: We will never use corruptible, epidemiological survey research as causal science. For each short/sharable video, the original Youtube links are provided above. None of this content is intended to be individual, personalized medical advice. We hope you find value for yourself in these videos & find them easy to share with loved ones! DISCLAIMER The DoctorsToTrust videos are for general informational purposes only and do not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. 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Aired: May 12, 2025
