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And we know that its the go to medicine for early diabetes, having tremendous benefits on insulin sensitivity, but we also know that it has many other health benefits for people who dont have diabetes at all, like PCOS, weight, fertility, etc. Metformin Side Effects. Metformin for Hair Growth. The first one is: Hair Growth. The short answer is that metformin does not cause hair loss. Its the conditions metformin is used to treat, that are well-known to be associated with hair loss. Not the metformin. So for example, PCOS which can lead to female androgenetic alopecia causing hair loss, and type 2 diabetes, which we know affects estrogen levels, especially in women to be associated with weakening and thinning of hair strands, causing hair loss. Here is what we know, the possible ability for metformin to improve cutaneous wound healing, which includes potentially regenerating the hair follicle. Although the study was on a mouse model, what I did find interesting was, the “discovery that chronic topical administration of Metformin and Resveratrol, but not RAPAMYCIN, accelerated wound healing with improved epidermis, hair follicles, and collagen deposition in young rodents. ► Metformin Side Effects. Yellow Nails With Metformin. The study shows us its a rare entity. So not to worry. And I found this to be quite bizarre actually. ► Metformin Side Effects. Metallic Taste With Metformin This is because of the presence of metformin in the saliva. Usually medicines make there way into the saliva, especially if there are hydrophilic. Metformin is a hydrophilic and positively charged molecule that relies on transporters to move across cell membranes, especially OCT proteins that are transporters. These transporters may also influence metformin transport in salivary glands. This is why to help get around this, you can try drinking plenty of water and staying hydrated or by chewing sugarless gum to help with any dry mouth and lessen the metallic taste. ► Metformin Side Effects. Loss of Eyebrows and Eyelashes. But metformin alone wasnt to blame. Again, this is a rare occurrence. In this study, a 69-year-old man with type 2 diabetes developed sudden loss of eyebrows and eyelashes about 4 months after the beginning of Janumet, which is a combo of metformin with sitagliptin. But keep in mind the Naranjo probability scale documented a possible association not a definite association. ► Metformin Side Effects. Metformin and Anti Aging. The theory that metformin for longevity is due to the mechanism by which metformin improves the body's responsiveness to insulin, which as we age, the efficiency in doing so slows down. 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Aired: May 12, 2025