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As a result, they experience little to no benefit from creatine supplementation. When you first start taking creatine, it takes time for your muscles to become fully saturated with that additional creatine. How long this takes depends on how much creatine you take every day. Using the loading method, it’ll take about 7 days to fully saturate your muscles. The other method is to take a baseline dose of creatine every day and to slowly increase your creatine levels overtime, often taking about 2-3 weeks to reach full saturation. Both methods get you to the same end destination, but will differ in some of the creatine side effects you may experience. For example, one of the side effects most people experience during this saturation phase is water retention and a small spike in your bodyweight. Another often reported side effect is stomach discomfort. If you experience this, or want to avoid experiencing it in the first place, try splitting up your creatine dose into multiple smaller doses throughout the day if you’re on the loading protocol. If it doesn’t work, stick with the non-loading protocol. In addition to this, avoid taking creatine on an empty stomach or with caffeine as those both scenarios seem to increase the likelihood of an upset stomach. Lastly, when you take your creatine, you can try mixing it with hot water to get it fully dissolved and see if that helps. Alright so the last side effect you and your doctor should know about has to do with your creatinine levels. Creatinine is a breakdown product of creatine. Since you’re taking more creatine, your creatinine levels will also slightly increase. And since high creatinine levels can indicate impaired kidney function, this can be alarming to see on a blood test if you’re not aware of it. 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Aired: May 12, 2025
