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When analyzed by subgroups, there was little to no beneficial effect on healthy individuals, but there was an improvement in lipids with people with cardiovascular disease and abnormal lipids (PMID 3530395). My hypothesis with NAD was that supplementation likely was less effective than another well-documented modality to increase NAD: routine exercise. Routine exercise has already been proven to improve cardiometabolic markers and longevity. NAD levels do decline as we age, but this paper examined the available evidence and concluded that routine exercise protects against age-related NAD level decline and that the effect of exercise is greater than that of NAD precursor supplementation. I do not take NAD supplements, and the benefits are greatly exaggerated based on where human research is today, and the harms are downplayed. 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Aired: May 12, 2025
