A group of drugs commonly used to treat erectile dysfunction can increase the effect of chemotherapy on esophageal cancer, according to new research funded by Cancer Research UK and the Medical Research Council. #Erectiledysfunction #drugsmay #ableboost #effectchemotherapy A group of drugs commonly used to treat erectile dysfunction can be able to stimulate the effect of chemotherapy in esophagus cancer, according to new research funded by Cancer Research UK and the Medical Research Council. This research, published today in Cell reputs Medicine, revealed that drugs, known as PDE5 inhibitors, can reverse resistance to chemotherapy by targeting cells called fibroblasts associated with cancer residing in the area surrounding the tumor. Although it is early research on discovery, PDE5 inhibitors combined with chemotherapy can be able to reduce the esophageal tumors that chemotherapy could not fight against chemotherapy resistance, which is 'One of the major challenges in the treatment of esophagus cancer. Esophagus cancer affects the food hose that connects your mouth to your stomach, and although it is relatively rare cancer, the United Kingdom has one of the higher rates in the world, with 9 300 new cases of esophagus cancer in the United Kingdom each year. Currently, this disease has much lower treatment and treatment options compared to other cancers, with around 1 in 10 survivor to their illness for 10 years or more. Part of this is that, in many cases, it can be resistant to chemotherapy, with around 80% of people who do not respond. Resistance to chemotherapy in esophagus cancer is influenced by tumor microenvironnement, the area that rings the tumor. This is made up of molecules, blood vessels and cells such as fibroblasts associated with cancer, which are important for tumor growth. It feeds the tumor and can act as a protective cape, preventing treatments like chemotherapy from having an effect. The team of researchers led by Professor Tim Underwood of the University of Southampton wanted to identify the cells of the tumor microenvironnement which protects the tumor from the treatment so that they can target them. The researchers discovered that the PDE5 levels, an enzyme initially found in the wall of the blood vessels are higher in esophageal adenocarcinoma compared to healthy esophageal tissue. High levels of PDE5 have been found in CAF in tumor microenvironment. They also found that a high expression of PDE5 is associated with a worse overall survival, which suggests that the PDE5 would be an effective target for treatment. After that, the researchers tested a PDE5 inhibitor, PDE5I, on the CAF of esophageal tumors. 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Aired: May 12, 2025
