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We will also share an update from Amy Kane who told her story of losing 160 pounds on weight loss medications last year on Oprah’s ABC Special: Shame, Blame and the Weight Loss Revolution. 00:00:00 Welcome Dr. Ania Jastreboff 00:01:34 The difference between obesity and being overweight 00:03:14 Is obesity a disease? 00:05:33 Why are some people prone to obesity and not others? 00:08:28 How your brain plays a role in obesity 00:10:31 We eat more food than our bodies need 00:13:00 Oprah shares about being publicly shamed for her weight 00:14:20 Can we control our weight? 00:20:18 Why GLP-1 medications are a game-changer for so many people 00:20:58 How GLP-1 medications work 00:23:35 Amy joins Oprah to share her weight loss journey 00:26:11 The biggest misconceptions about GLP-1 weight loss drugs 00:29:00 Understanding food noise 00:31:12 Amina joins Oprah to share her weight loss journey 00:33:35 Do you need to stay on GLP-1 medications forever? 00:37:03 GLP-1 medications are not a weight loss drug 00:39:41 Emma joins Oprah to share her weight loss journey 00:42:58 Long-term effects of taking GLP-1 medications 00:48:23 Side effects of GLP-1 Also referenced in this episode: "The Let Them Theory: A Life-Changing Tool That Millions of People Can’t Stop Talking About" by Mel Robbins, published by Hay House LLC is available wherever books and audio books are sold: SUPPORT THE SHOW Subscribe: Find Oprah’s Interview with Mel Robbins here: Follow Amy on Instagram: Follow Amy on TikTok Follow Emma on TikTok Follow Emma on Instagram Follow Oprah Winfrey on Social: Listen to the full podcast: The long hair increased the voice and shouted chestnut. 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Aired: May 12, 2025